A 94-year-old woman became the first elderly person to receive the vaccine against coronavirus on Friday.
Mary Pizzuto received the jab at St Vincent De Paul where she lives.
Another 40 elderly residents and 15 staff members will also be vaccinated throughout the day.
Elderly people in other residences will be vaccinated in the coming days.
In a comment, Active Ageing Minister Michael Farrugia thanked all the frontliners who for months have been working with the elderly as well as the elderly themselves.
The vaccines arrived in Malta on Saturday while the mass vaccination programme was rolled out on Sunday as the EU started vaccinating its citizens against the deadly virus.
Mater Dei Hospital staff nurse Rachel Grech, who works at the Infectious Disease Unit became the first person to take the vaccine in Malta.